Therefore, we studied the consequences of global LPA 5 knockout ( -/-) on neuroinflammatory parameters in a mouse endotoxemia model and in primary microglia exposed to LPA in vitro. Engagement of LPA 5 by LPA polarizes microglia toward a pro-inflammatory phenotype. In mouse and human microglia, LPA 5 belongs to a set of receptors that cooperatively detect danger signals in the brain. In the CNS, these changes include increased synthesis of the bioactive lipid lysophosphatidic acid (LPA), a ligand for the six members of the LPA receptor family (LPA 1-6). Please provide a download link to the After Effects file that demonstrates the problem.Systemic inflammation induces alterations in the finely tuned micromilieu of the brain that is continuously monitored by microglia. There is a pinching / thinning of the stroke weight that occurs at the beginning of the loop.
What actually happened? Please include as much relevant detail as possible.Īctual Behavior: The stroke weight is not consistent. Stroke weight is consistent and there is no "pinching" of the stroke weight:
The Trim Paths layer is also being matted out by an Inverted Alpha MatteĮxpected Behavior should look like this. What did you do? Please explain the steps you took before you encountered the problem. Not sure what version of Lottie they are running.Ĭhrome Version 1.79 (Official Build) (x86_64) This issue does not happen on iOS or Android. So there seems to be an issue with how Gradient Strokes are rendered on Web. But when changed back to a Gradient Stroke, the stroke width is pinching/thinning out in an unintended way. This might be an issue with the Gradient Stroke, because when I change the Gradient stroke to a normal stroke, the stroke width looks correct. For some reason, my Gradient Stroke weight is getting pinched and thinned out at the beginning of the animation, but it should be a consistent stroke width.
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